Binding And UV/Vis Spectral Investigation of Interaction of Ni(II) Piroxicam Complex With Calf Thymus Deoxyribonucleic Acid (Ct-DNA) : A Thermodynamic Approach
نویسنده
چکیده
In this study the interaction of the complex with DNA have been investigated using UV/Vis , and thermal denaturation.The results showed that complex Ni(Pirox)2(DMF)2 can bind to ct-DNA. The binding constants of the complex with ct-DNA have also been calculated. The thermodynamic parameters for binding of complex with ct-DNA are also determined using van’t Hoff equation. Competitive binding with ethidium bromide (EB) indicate that the complex could not intercalate in the DNA.
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تاریخ انتشار 2015